ICCB-Longwood Screening Facility
ICCB-Longwood uses an integrated linear platform that includes the Agilent 4-R BenchCel, Bravo and PlateLoc. This setup, contained in…
Robotic Production of Cancer Cell Spheroids with an Aqueous Two-phase System for Drug Testing
ABSTRACT Cancer cell spheroids present a relevant in vitro model of avascular tumors for anti-cancer drug testing applications. A detailed…
Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51
Abstract Background Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America…
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch
Abstract The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for…
A genome wide RNA interference screening method to identify host factors that modulate Influenza A virus replication
The use of genome wide RNA interference (RNAi) screens to investigate host-viral interactions has revealed unexpected…
Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic Tips
Abstract Disposable plastic labware is ubiquitous in contemporary pharmaceutical research laboratories. Plastic labware is…